Transfer factor (TF), also known as “Lawrence transfer factor” or dialyzable leukocyte extract (DLE), has been utilized since the mid-20th century to convey specific skin hypersensitivity via injections of leukocytes from immunized donors to both animals and humans.
Primarily, transfer factors are employed to combat infections, particularly in individuals with weakened immune systems. They are also investigated for various conditions, including certain cancers, Crohn’s disease, chronic fatigue syndrome (CFS), and more, although scientific evidence supporting these uses is limited.
How Does It Work?
Transfer factor may enhance immunity against specific diseases.
Uses & Effectiveness
Possibly Effective For:
Shingles (herpes zoster): Administering transfer factor as a subcutaneous injection may prevent shingles in children with leukemia. However, it does not seem to prevent recurrent shingles or restore protection in individuals who have undergone bone marrow transplants for leukemia. For those with shingles, it may reduce pain duration compared to acyclovir.
Possibly Ineffective For:
Lung cancer: Some studies have explored combining transfer factor shots with standard lung cancer treatments like surgery and chemotherapy. However, it generally does not improve survival rates in most lung cancer patients. Preliminary research suggests it may enhance survival in advanced-stage lung cancer.
Melanoma: When used alongside standard treatments, transfer factor does not appear to slow disease progression or extend survival in patients following surgery for Stage I and II melanoma.
Multiple sclerosis (MS): Most studies indicate that transfer factor does not slow disease progression. Some research suggests a potential effect in patients with mild to moderate symptoms, but this may take 18 months to 2 years of treatment to manifest.
Side Effects
Oral Administration: Transfer factors derived from humans or cows are generally considered possibly safe for adults. Some individuals may experience fever. There are concerns about the risk of “mad cow disease” (bovine spongiform encephalopathy, BSE) or other diseases from animal-derived products. While transfer factor has not been linked to BSE transmission, it is prudent to avoid animal products from countries where BSE has been reported.
Injection: When administered as an intramuscular or subcutaneous injection, transfer factors from humans or cows are also considered possibly safe for adults. They may cause fever, swelling, and pain at the injection site. The same concerns regarding BSE apply as with oral administration.
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